Personalized service:We may provide you with customized services in store based on your earlier purchases with us, and information regarding your clothing/shopping preferences that you have voluntarily shared with our staff. We aim to provide this service in all countries where we have our own stores, including but not limited to Sweden, Norway, Denmark, Germany, France, Italy, the United Kingdom, Australia, the United States, Japan and South Korea.
A major mechanism of acne-related skin inflammation is mediated by C. acnes's ability to bind and activate a class of immune system receptors known as toll-like receptors (TLRs), especially TLR2 and TLR4. Activation of TLR2 and TLR4 by C. acnes leads to increased secretion of IL-1α, IL-8, and TNF-α. Release of these inflammatory signals attracts various immune cells to the hair follicle including neutrophils, macrophages, and Th1 cells. IL-1α stimulates increased skin cell activity and reproduction, which in turn fuels comedo development. Furthermore, sebaceous gland cells produce more antimicrobial peptides, such as HBD1 and HBD2, in response to binding of TLR2 and TLR4.